Browsing by Author "Faúndez, Mario"

Now showing items 1-13 of 13

    • Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and ... 
      Faúndez, Mario; López Muñoz, Rodrigo; Torres, Gloria; Morello Casté, Antonio; Ferreira, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Maya Arango, Juan (AMER SOC MICROBIOLOGY, 2008)
      L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
    • Copper modifies liver microsomal UDP-glucuronyltransferase activity through different and opposite mechanisms 
      Letelier Muñoz, María Eugenia; Lagos, Fernando; Faúndez, Mario; Miranda, Dante; Montoya, Margarita; Aracena Parks, Paula; González Lira, Víctor (ELSEVIER IRELAND LTD, 2007-04)
      Treatment of hepatic microsomes with Fe3+/ascorbate activates UDP-glucuronyltransferase (UGT), a phenomenon totally prevented and reversed by reducing agents. At #2;M concentrations, iron and copper ions catalyze the ...
    • Effect of alpha lipoic acid on leukotriene A4 hydrolase 
      Torres, María José; Fierro, Angélica; Pessoa Mahana, Carlos David; Romero Parra, Javier; Cabrera Vallejos, Gonzalo; Faúndez, Mario (Elsevier, 2017)
      Leukotriene A(4) hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A(4) to leukotriene B-4 and the hydrolysis of the peptide proline-glycine-proline. ...
    • Evaluation of the antioxidant properties and effects on the biotransformation of commercial herbal preparations ... 
      Letelier, María Eugenia; Cortes, Juan; Lepe, Ana; Jara, José; Molina Berríos, Alfredo; Rodriguez, Carmen; Iturra-Montecinos, Pablo; Faúndez, Mario (2009)
      The antioxidant herbal ingredients are xenobiotics for animals, many of them must be biotransformed to be eliminated, especially lipophilic compounds. Biotransformation of such xenobiotics- occurs mainly in the hepatic ...
    • Inhibition of cytosolic glutathione S-transferase activity from rat liver by copper 
      Letelier Muñoz, María Eugenia; Martínez, M.; González Lira, Víctor; Faúndez, Mario; Aracena Parks, Paula (ELSEVIER, 2006-12-01)
      H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...
    • Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism 
      Letelier, María Eugenia; Jara Sandoval, José; Molina Berríos, Alfredo Enrique; Faúndez, Mario; Aracena-Parks, Paula; Aguilera, Felipe (2010)
      Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
    • Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the ... 
      Maya Arango, Juan; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio; Ferreira, Jorge; Faúndez, Mario; Galanti Garrone, Norbel; Ferreira Vigouroux, Luis Arturo; Morello Casté, Antonio (2007)
      Current knowledge of the biochemistry of Trypanosonta cruzi has led to the development of new drugs and the understanding of their mode of action. Some trypanocidal drugs such as nifurtimox and benznidazole act through ...
    • Natural and synthetic naphthoquinones active against Trypanosoma cruzi: An initial step towards new drugs ... 
      Salas, Cristian O.; Faúndez, Mario; Morello Casté, Antonio; Maya Arango, Juan; Tapia, Ricardo A. (2011)
      Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...
    • New pyridone-based derivatives as cannabinoid receptor type 2 agonists 
      Faúndez Parraguez, Manuel; Alarcón Miranda, Carlos; Cho, Young Hwa; Pessoa Mahana, Hernan Armando; Gallardo Garrido, Carlos; Chung, Hery; Faúndez, Mario; Pessoa Mahana, David (MDPI, 2021)
      The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
    • Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity 
      Letelier Muñoz, María Eugenia; Lepe, Ana María; Faúndez, Mario; Salazar, Julia; Marín Catalán, Rigoberto; Aracena Parks, Paula; Speisky Cosoy, Hernán (ELSEVIER SCI IRELAND, 2005-01-15)
      It is generally accepted that copper toxicity is a consequence of the generation of reactive oxygen species (ROS) by copper ions via Fenton or Haber-Weiss reactions. Copper ions display high affinity for thiol and amino ...
    • Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a ... 
      Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Henriquez, Natalia; Faúndez, Mario; Torres, Gloria; Castillo, Christian; Escanilla, Sebastián; Kemmerling Weis, Ulrike; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Public Library of Science, 2013)
      Chagas' disease, produced by Trypanosoma cruzi, affects more than 8 million people, producing approximately 10,000 deaths each year in Latin America. Migration of people from endemic regions to developed countries has ...
    • Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core 
      Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)
      © 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
    • Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole 
      López Muñoz, Rodrigo; Faúndez, Mario; Klein, Sebastián; Escanilla, Sebastián; Torres, Gloria; Lee-Liu, Dasfne; Ferrada Parker, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Morello Casté, Antonio; Ferreira, Arturo; Maya Arango, Juan (ELSEVIER, 2010)
      Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an antiparasitic ...